Manager Alex Cora said Thursday that Pedroia will come off the disabled list for a weekend series at Fenway Park against Atlanta.
Pedroia's return to the AL East leaders will come exactly seven months after cartilage-restoration surgery on his left knee. He played his final game for Triple-A Pawtucket on Thursday, finishing 1-for-14 in his five-game rehab assignment.
"He's saving his hits for Fenway," Cora joked. "He was able to track pitches, and he had seven- and eight-pitch at-bats, so he'll be fine. The fact that he was able to play today, full-out, with no concerns, that's good enough for me."
The 34-year-old Pedroia is in his 13th season with the Red Sox. He was the American League MVP in 2008 and ranks sixth among all Red Sox hitters in doubles (394) and stolen bases (138), and eighth in hits (1,802) and total bases (2,646).
Pedroia will start on either Friday or Saturday, and will bat somewhere in the lineup after first or second. Cora plans to stay with Mookie Betts and Andrew Benintendi in those spots.
"Now that (Pedroia) is healthy, he's going to be able to drive the ball, so he'll have a lot of traffic in front of him wherever he hits in the lineup," Cora said.
Eduardo Nunez, who has started most of Boston's games at second base so far this season, will go back to a utility role.
"He likes to move around," Cora said. "I do feel he's making progress at second base, making the routine plays, but now he doesn't have to grind it out at second the whole time. He can move around and the real Eduardo Nunez will come out."